Effects of medial frontal cortex lesions on DRL performance in rats

S Finger; K L Altemus; L Green; C Wolf; J Miller; C R Almli

doi:10.1016/0031-9384(87)90405-7

Effects of medial frontal cortex lesions on DRL performance in rats

Physiol Behav. 1987;41(4):387-9. doi: 10.1016/0031-9384(87)90405-7.

Authors

S Finger¹, K L Altemus, L Green, C Wolf, J Miller, C R Almli

Affiliation

¹ Department of Psychology, Washington University, St. Louis, MO 63130.

PMID: 3432390
DOI: 10.1016/0031-9384(87)90405-7

Abstract

Rats with medial frontal cortical lesions (MFC) and control animals with sham operations were tested on an ascending series of 8 DRL schedules of reinforcement ranging from 5 to 70 seconds. Rats with MFC lesions did not differ from the control group in performance when response rate, responses per reinforcement and efficiency were analyzed. These results indicate that deficits in "response inhibition" often displayed by rats with MFC lesions may be task-specific.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Cerebral Cortex / physiology*
Conditioning, Operant / physiology*
Frontal Lobe / physiology*
Male
Rats
Reinforcement Schedule*
Time Factors

Grants and funding

SO7 RR07054-19/RR/NCRR NIH HHS/United States