Colchicine Toxicity: The Fatal Masquerader

Vinaya Mulkareddy; Carly Sokach; Eric Bucklew; Abdallah Bukari; Alexander Sidlak; Ian M Harrold; Anthony Pizon; Steven Reis

doi:10.1016/j.jaccas.2020.02.014

Colchicine Toxicity: The Fatal Masquerader

JACC Case Rep. 2020 Apr 15;2(4):678-680. doi: 10.1016/j.jaccas.2020.02.014. eCollection 2020 Apr.

Authors

Vinaya Mulkareddy¹, Carly Sokach², Eric Bucklew², Abdallah Bukari¹, Alexander Sidlak³, Ian M Harrold⁴, Anthony Pizon³, Steven Reis¹

Affiliations

¹ Department of Cardiology, University of Pittsburgh Medical Center Presbyterian, Pittsburgh, Pennsylvania.
² Department of Internal Medicine, University of Pittsburgh Medical Center Presbyterian, Pittsburgh, Pennsylvania.
³ Department of Toxicology, University of Pittsburgh Medical Center Presbyterian, Pittsburgh, Pennsylvania.
⁴ Department of Pathology, University of Pittsburgh Medical Center Presbyterian, Pittsburgh, Pennsylvania.

Abstract

Colchicine toxicity results in fatal multiorgan failure. We present a case of colchicine toxicity resulting in transient biventricular failure and cardiogenic shock that were successfully treated with packed red blood cell exchange. (Level of Difficulty: Beginner.).

Keywords: CO, cardiac output; CRRT, continuous renal replacement therapy; LVEF, left ventricular ejection fraction; PAD, pulmonary artery diastolic pressure; PRBC, packed red blood cell; RBC, red blood cell; SVRI, systemic vascular resistance indexed; biventricular failure; cardiogenic shock; colchicine toxicity; packed red blood cell exchange.

Publication types

Case Reports