Neurobiology: Resetting the axon's batteries

Jeffery L Twiss; Ashley L Kalinski; Pabitra K Sahoo; Irene Dalla Costa; Roman J Giger

doi:10.1016/j.cub.2021.06.014

Neurobiology: Resetting the axon's batteries

Curr Biol. 2021 Jul 26;31(14):R914-R917. doi: 10.1016/j.cub.2021.06.014.

Authors

Jeffery L Twiss¹, Ashley L Kalinski², Pabitra K Sahoo³, Irene Dalla Costa³, Roman J Giger⁴

Affiliations

¹ Department of Biological Sciences, University of South Carolina, Columbia, SC 20208, USA. Electronic address: twiss@mailbox.sc.edu.
² Department of Biology, Ball State University, Muncie, IN 47306, USA.
³ Department of Biological Sciences, University of South Carolina, Columbia, SC 20208, USA.
⁴ Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

Neuronal injury can cause mitochondrial damage, leading to reduced energy production, decreased Ca²⁺ storage capacity, and increased reactive oxygen species. A new study reveals a mechanism to trigger the axonal transport of previously anchored mitochondria and promote neuroprotection and axon regeneration by replacing damaged with functional mitochondria.

Publication types

Comment

MeSH terms

Axonal Transport
Axons* / metabolism
Nerve Regeneration*
Neurobiology
Neurons

Abstract

Publication types

MeSH terms

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