No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants

Qiangsheng He; Bin Xia; Wenbo Meng; Die Fan; Zi-Chong Kuo; Junjie Huang; Xiwen Qin; Huachun Zou; Yulong He; Changhua Zhang; Shuo Fang; Yihang Pan; Man Yang; Jinqiu Yuan

doi:10.14309/ajg.0000000000001377

No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants

Am J Gastroenterol. 2021 Nov 1;116(11):2286-2291. doi: 10.14309/ajg.0000000000001377.

Authors

Qiangsheng He^{1

2}, Bin Xia^{1

2}, Wenbo Meng³, Die Fan², Zi-Chong Kuo⁴, Junjie Huang⁵, Xiwen Qin^{6

7

8}, Huachun Zou^{9

10}, Yulong He^{1

4}, Changhua Zhang⁴, Shuo Fang¹¹, Yihang Pan^{1

4}, Man Yang^{3

4}, Jinqiu Yuan^{1

2

4}

Affiliations

¹ Big Data Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
² Clinical Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
³ Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
⁴ Guangdong Provincial Key Laboratory of Gastrointestinal Cancers, Center for Digestive Disease, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
⁵ JC School of Public Health, The Chinese University of Hong Kong, Shatin, Hong Kong.
⁶ Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Science, Monash University, Melbourne, Australia.
⁷ Victorian Heart Institute, Monash University, Melbourne, Australia.
⁸ School of Population and Global Health, Faculty of Medicine, Density and Health Sciences, University of Western Australia, Perth, Australia.
⁹ School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China.
¹⁰ Kirby Institute, University of New South Wales, Sydney, Australia.
¹¹ Department of Oncology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.

Abstract

Introduction: The association between proton pump inhibitors' (PPIs) use and mortality remains unclear.

Methods: This was a prospective analysis of 440,840 UK residents and 13,154 deaths. We evaluated the associations with multivariate Cox regression.

Results: After adjusting for confounders, such as over health status and longstanding diseases, the regular use of PPIs was not associated with an increased risk of all-cause mortality and mortality due to neoplasms, circulatory system diseases, respiratory system diseases, digestive system diseases, external causes, and other causes.

Discussion: Regular use of PPIs was not associated with an increased risk of all-cause and cause-specific mortality.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Cause of Death*
Cohort Studies
Female
Humans
Male
Middle Aged
Prospective Studies
Proton Pump Inhibitors / adverse effects*
Risk Assessment

Substances

Proton Pump Inhibitors