Malignant transformation in a cohort of patients with oral epithelial dysplasia

P M Hankinson; R I Mohammed-Ali; A T Smith; S A Khurram

doi:10.1016/j.bjoms.2021.02.019

Malignant transformation in a cohort of patients with oral epithelial dysplasia

Br J Oral Maxillofac Surg. 2021 Nov;59(9):1099-1101. doi: 10.1016/j.bjoms.2021.02.019. Epub 2021 Mar 3.

Authors

P M Hankinson¹, R I Mohammed-Ali², A T Smith³, S A Khurram⁴

Affiliations

¹ Unit of Oral and Maxillofacial Pathology, The School of Clinical Dentistry, Claremont Crescent, Sheffield S10 2TA, UK. Electronic address: p.hankinson@sheffield.ac.uk.
² Department of Oral and Maxillofacial Surgery, Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Road, Sheffield S10 2JF, UK. Electronic address: ricardomohammed-ali@nhs.net.
³ Department of Oral and Maxillofacial Surgery, Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Road, Sheffield S10 2JF, UK. Electronic address: austensmith@sheffield.ac.uk.
⁴ Unit of Oral and Maxillofacial Pathology, The School of Clinical Dentistry, Claremont Crescent, Sheffield S10 2TA, UK. Electronic address: s.a.khurram@sheffield.ac.uk.

PMID: 34303542
DOI: 10.1016/j.bjoms.2021.02.019

Abstract

Oral epithelial dysplasia (OED) is often diagnosed in oral potentially malignant disorders (OPMD) and carries an increased risk of malignant transformation. Currently, the reported risk of malignant transformation for OED varies. Here we present the risk in a cohort of 150 patients with OED at a specialist centre. In this cohort 2.6%, 4.1%, and 29.2% cases of mild, moderate, and severe OED, respectively, progressed to oral squamous cell carcinoma at the dysplastic site, while a small number developed a malignant lesion elsewhere. Moreover, 17 patients experienced an increase in grade of dysplasia and two showed histological resolution of their lesions.

Keywords: Malignant transformation; oral epithelial dysplasia; oral potentially malignant disorders.

MeSH terms

Carcinoma, Squamous Cell*
Cell Transformation, Neoplastic
Humans
Leukoplakia, Oral
Mouth Mucosa
Mouth Neoplasms*
Precancerous Conditions*