Subsetting the subsets: Heterogeneity and developmental relationships of T cells in human tumors

Sci Immunol. 2021 Jul 23;6(61):eabj3067. doi: 10.1126/sciimmunol.abj3067.

Cécile Alanio^{1

2

3

4

5}, E John Wherry^{6

2

3

7}

¹ Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
² Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
³ Parker Institute for Cancer Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
⁴ INSERM U932, PSL University, Institut Curie, Paris 75005, France.
⁵ Laboratoire d'immunologie clinique, Institut Curie, Paris 75005, France.
⁶ Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. wherry@pennmedicine.upenn.edu.
⁷ Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Abstract

High-dimensional profiling approaches inform developmental relationships between tumor-infiltrating lymphocyte subpopulations.