Interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases

Sulagna Bhattacharya; Sakshi Agarwal; Nishith M Shrimali; Prasenjit Guchhait

doi:10.1016/j.mam.2021.101000

Interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases

Mol Aspects Med. 2021 Oct:81:101000. doi: 10.1016/j.mam.2021.101000. Epub 2021 Jul 19.

Authors

Sulagna Bhattacharya¹, Sakshi Agarwal², Nishith M Shrimali², Prasenjit Guchhait³

Affiliations

¹ Regional Centre for Biotechnology, National Capital Region Biotech Science Cluster, Faridabad, India; School of Biotechnology, Kalinga Institute of Industrial Technology, Orissa, India.
² Regional Centre for Biotechnology, National Capital Region Biotech Science Cluster, Faridabad, India.
³ Regional Centre for Biotechnology, National Capital Region Biotech Science Cluster, Faridabad, India. Electronic address: prasenjit@rcb.res.in.

Abstract

History of pandemics is dominated by viral infections and specifically respiratory viral diseases like influenza and COVID-19. Lower respiratory tract infection is the fourth leading cause of death worldwide. Crosstalk between resultant inflammation and hypoxic microenvironment may impair ventilatory response of lungs. This reduces arterial partial pressure of oxygen, termed as hypoxemia, which is observed in a section of patients with respiratory virus infections including SARS-CoV-2 (COVID-19). In this review, we describe the interplay between inflammation and hypoxic microenvironment in respiratory viral infection and its contribution to disease pathogenesis.

Keywords: Hypoxia and hypoxemia; Immune response; Inflammation; Respiratory virus.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

COVID-19*
Humans
Hypoxia
Inflammation
Pandemics
SARS-CoV-2