Biosynthesis of napyradiomycins

K Shiomi; H Iinuma; H Naganawa; K Isshiki; T Takeuchi; H Umezawa

doi:10.7164/antibiotics.40.1740

Biosynthesis of napyradiomycins

J Antibiot (Tokyo). 1987 Dec;40(12):1740-5. doi: 10.7164/antibiotics.40.1740.

Authors

K Shiomi¹, H Iinuma, H Naganawa, K Isshiki, T Takeuchi, H Umezawa

Affiliation

¹ Institute of Microbial Chemistry, Tokyo, Japan.

PMID: 3429338
DOI: 10.7164/antibiotics.40.1740

Abstract

Biosynthetic studies on napyradiomycins were carried out based on the incorporation of [2-13C]acetate and [1,2-13C]acetate. The alignment of acetate units suggested that the B and C rings of napyradiomycins are derived from a pentaketide, while ring A and the side chain may be synthesized from mevalonate.

MeSH terms

Acetates / metabolism
Actinomycetales / metabolism*
Anti-Bacterial Agents / biosynthesis*
Magnetic Resonance Spectroscopy
Mevalonic Acid / metabolism
Naphthoquinones / biosynthesis

Substances

Acetates
Anti-Bacterial Agents
Naphthoquinones
napyradiomycin C2
napyradiomycin C1
napyradiomycin B1
napyradiomycin A1
napyradiomycin A2
Mevalonic Acid