Research progress of omics technology in the field of tumor resistance: From single - omics to multi - omics combination application

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Jun 28;46(6):620-627. doi: 10.11817/j.issn.1672-7347.2021.200561.
[Article in English, Chinese]

Abstract
in English, Chinese

Drug resistance is the main obstacle in the treatment of many cancers. It is of great clinical significance to study the mechanism of drug resistance and find new targets. Multi-omics mainly includes genomics, epigenomics, transcriptomics, proteomics, metabolomics, and radiomics. In recent years, the research of tumor resistance has made rapid development, which has significantly accelerated the discovery of new targets.

耐药是癌症治疗面临的主要难题，明确肿瘤耐药机制和寻找新的药物靶点有重要的临床意义。多组学主要包括基因组学、表观基因组学、转录组学、蛋白质组学、代谢组学、影像组学等。近年来，肿瘤耐药研究从单组学到多组学联合，取得了飞速的发展，显著加快了肿瘤新的药物靶点的发现。.

Keywords: epigenomics; genomics; metabolomics; proteomics; radiomics; transcriptomics; tumor resistance.

MeSH terms

  • Epigenomics
  • Genomics*
  • Humans
  • Metabolomics
  • Neoplasms* / genetics
  • Proteomics
  • Technology