Influence of Maternal Lifestyle and Diet on Perinatal DNA Methylation Signatures Associated With Childhood Arterial Stiffness at 8 to 9 Years

Hypertension. 2021 Sep;78(3):787-800. doi: 10.1161/HYPERTENSIONAHA.121.17396. Epub 2021 Jul 19.

Robert Murray¹, Negusse Kitaba¹, Elie Antoun^{1

2}, Philip Titcombe³, Sheila Barton³, Cyrus Cooper³, Hazel M Inskip^{3

4}, Graham C Burdge¹, Pamela A Mahon³, John Deanfield⁵, Julian P Halcox⁶, Elizabeth A Ellins⁶, Jennifer Bryant⁷, Charles Peebles⁸, Karen Lillycrop^{2

4}, Keith M Godfrey^{1

3

4}, Mark A Hanson^{1

4}; EpiGen Consortium

¹ From the School of Human Development and Health, Institute of Developmental Sciences Building, Faculty of Medicine (R.M., N.K., E.A., G.C.B., K.M.G., M.A.H.), University of Southampton, United Kingdom.
² Centre for Biological Sciences, Faculty of Natural and Environmental Sciences (E.A., K.L.), University of Southampton, United Kingdom.
³ MRC Lifecourse Epidemiology Unit (P.T., S.B., C.C., H.M.I., P.A.M., K.M.G.), University of Southampton, United Kingdom.
⁴ NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, United Kingdom (H.M.I., K.L., K.M.G., M.A.H.).
⁵ Institute of Cardiovascular Sciences, University College London, United Kingdom (J.D.).
⁶ Swansea University Medical School, Swansea University, United Kingdom (J.P.H., E.A.E.).
⁷ Department of Cardiac Magnetic Resonance Imaging, National Heart Centre Singapore (J.B.).
⁸ Wessex Cardiothoracic Centre, Southampton University Hospitals NHS Trust, United Kingdom (C.P.).

Abstract

[Figure: see text].

Keywords: DNA methylation; aorta; blood pressure; epigenome; genetic variation.