As an alternative inertial confinement fusion scheme, shock ignition requires a strong converging shock driven by a high-intensity laser pulse to ignite a precompressed fusion capsule. Understanding nonlinear laser-plasma instabilities is crucial to assess and improve the laser-shock energy coupling. Recent experiments conducted on the OMEGA EP laser facility have demonstrated that such instabilities can ∼100% deplete the first 0.5 ns of the high-intensity laser. Analyses of the observed laser-generated blast wave suggest that this pump-depletion starts at ∼0.02 critical density and progresses to 0.1-0.2 critical density, which is also confirmed by the time-resolved stimulated Raman backscattering spectra. The pump-depletion dynamics can be explained by the breaking of ion-acoustic waves in stimulated Brillouin scattering. Such pump depletion would inhibit the collisional laser energy absorption but may benefit the generation of hot electrons with moderate temperatures for electron shock ignition [Phys. Rev. Lett. 119, 195001 (2017)PRLTAO0031-900710.1103/PhysRevLett.119.195001].