Breakthroughs and bottlenecks in autophagy research

Noboru Mizushima; Eileen White; David C Rubinsztein

doi:10.1016/j.molmed.2021.06.012

Breakthroughs and bottlenecks in autophagy research

Trends Mol Med. 2021 Sep;27(9):835-838. doi: 10.1016/j.molmed.2021.06.012. Epub 2021 Jul 11.

Authors

Noboru Mizushima¹, Eileen White², David C Rubinsztein³

Affiliations

¹ Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan. Electronic address: nmizu@m.u-tokyo.ac.jp.
² Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA; Ludwig Institute for Cancer Research, Ludwig Princeton Branch, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: epwhite@cinj.rutgers.edu.
³ Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge, UK; UK Dementia Research Institute, Cambridge Biomedical Campus, Cambridge, UK. Electronic address: dcr1000@cam.ac.uk.

PMID: 34257008
DOI: 10.1016/j.molmed.2021.06.012

Abstract

The study of autophagy has grown exponentially over the past two decades, and significant progress has been made in our understanding of its mechanisms and physiological significance. However, its application to human diseases remains limited. Here, we summarize the current status of autophagy research, with a particular focus on human diseases.

Keywords: ATG genes; autophagic flux; macroautophagy; neurodegenerative disease; tumor growth.

Breakthroughs and bottlenecks in autophagy research

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