Abstract
Mechanical force applied by ultrasound in solution leads to the dissociation of DNA metallo-base-pair interactions when these motifs are functionalized with oligodeoxynucleotide sequences of sufficient length. The annealing and force-induced denaturing process is followed by the attachment of distance-sensitive fluorescent probes and is found to be reversible.
MeSH terms
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Base Pairing
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DNA / chemistry*
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DNA / genetics
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DNA / radiation effects
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Fluoresceins / chemistry
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Fluorescent Dyes / chemistry
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Nucleic Acid Hybridization / radiation effects
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Oligodeoxyribonucleotides / chemistry*
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Oligodeoxyribonucleotides / genetics
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Oligodeoxyribonucleotides / radiation effects
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Silver / chemistry*
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Ultrasonic Waves
Substances
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Fluoresceins
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Fluorescent Dyes
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Oligodeoxyribonucleotides
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Silver
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DNA