1 Systems Biology Ireland, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland. boris.kholodenko@ucd.ie mokada@protein.osaka-u.ac.jp.
2 Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland.
3 Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.
4 Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan. boris.kholodenko@ucd.ie mokada@protein.osaka-u.ac.jp.