Congenital cytomegalovirus (CMV) for the pediatric otolaryngologist

J Drew Prosser; Thomas W Holmes; Mohammad Seyyedi; Daniel I Choo

doi:10.1016/j.ijporl.2021.110809

Congenital cytomegalovirus (CMV) for the pediatric otolaryngologist

Int J Pediatr Otorhinolaryngol. 2021 Sep:148:110809. doi: 10.1016/j.ijporl.2021.110809. Epub 2021 Jun 24.

Authors

J Drew Prosser¹, Thomas W Holmes², Mohammad Seyyedi³, Daniel I Choo⁴

Affiliations

¹ Division of Pediatric Otolaryngology, Head and Neck Surgery, Medical College of Georgia, Augusta University, Augusta, GA, USA.
² Division of Pediatric Otolaryngology, Head and Neck Surgery, Medical College of Georgia, Augusta University, Augusta, GA, USA; Division of Otology and Neurotology, Head and Neck Surgery, Medical College of Georgia, Augusta University, Augusta, GA, USA. Electronic address: tholmes@augusta.edu.
³ Division of Otology and Neurotology, Head and Neck Surgery, Medical College of Georgia, Augusta University, Augusta, GA, USA.
⁴ Division of Pediatric Otolaryngology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

PMID: 34198225
DOI: 10.1016/j.ijporl.2021.110809

Abstract

Cytomegalovirus (CMV) is a double-stranded DNA virus and a member of the herpesvirus family. It is the most common congenital viral infection. For symptomatic infections, symptoms can vary widely but tends to have a predilection for the central nervous system and for the reticuloendothelial system. Sensorineural hearing loss (SNHL) is by far the most common sequelae of congenital CMV infection. For this reason, it is imperative to understand the screening, diagnosis, and possible treatment options for congenital CMV induced SNHL. This literature review explores the association of CMV with hearing loss, screening for congenital CMV infections, possible treatments options, and the development of a possible vaccine.

Keywords: CMV; Congenital cytomegalovirus; Cytomegalovirus; Hearing loss; SNHL; Sensorineural hearing loss.

Publication types

Review

MeSH terms

Child
Cytomegalovirus
Cytomegalovirus Infections* / complications
Cytomegalovirus Infections* / diagnosis
Hearing Loss, Sensorineural* / diagnosis
Hearing Loss, Sensorineural* / etiology
Humans
Otolaryngologists