1 Department of Medical Oncology, The Christie NHS Foundation Trust/Institute of Cancer Sciences, University of Manchester, Manchester M20 4BX,, UK.
2 University of Liverpool and Clatterbridge Cancer Centre, Liverpool, UK.
3 Department of Cancer Medicine, Hammersmith Hospital, Imperial Colllege London, London, UK.
4 Guy's Cancer, Guy's & St Thomas' NHS Foundation Trust, London, UK.
5 Department of Hepatobiliary Oncology, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
6 Department of Medical Oncology, University Hospital of Nottingham NHS Trust, University of Nottingham, Nottingham, UK.
7 Bristol Haematology and Oncology Centre, Bristol, UK.
8 Department of Medical Oncology, Royal Free NHS Foundation Trust, London, UK.
9 Weston Park Cancer Centre, Sheffield, UK.
10 Department of Medical Oncology, Cancer and Haematology Centre, Oxford, UK.
11 Department of Medical Oncology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
12 Department of Medical Oncology, Hull University Teaching Hospitals NHS Trust, Hull, UK.
13 Department of Gastro- Intestinal Oncology, University Hospital Southampton NHS Foundation Trust, Southampton University, Southampton, UK.
14 Kent Oncology Centre, Maidstone, UK.
15 Department of Clinical Oncology, Great Western Hospital, Swindon, UK.
16 Manchester Clinical Trials Unit, University of Manchester, Manchester M20 4BX, UK.
17 Hampshire Hospitals NHS Foundation Trust, Basingstoke, UK.
18 Manchester Centre for Health Economics, University of Manchester, Manchester M20 4BX, UK.
19 UCL Cancer Institute, University College London, London, UK.
20 Department of Medical Oncology, The Christie NHS Foundation Trust/Institute of Cancer Sciences, University of Manchester, Manchester M20 4BX,, UK; Division of Cancer Sciences, University of Manchester, Manchester M20 4BX, UK. Electronic address: juan.valle@manchester.ac.uk.