Abstract
We studied the effect of nanostructured clathrate complex 9-phenyl-symm-octahydoselenoxanthene (selenopyran) with β-cyclodextrin on the generation of ОН· radicals in the Fenton system and parameters of oxidative stress in rat liver cells incubated at 37°С for 1 h. The complex inhibits the development of free-radical oxidative processes induced by ROS and the most toxic ОН· radicals, reduces the increased level of ROS induced by prooxidants, and exhibits antioxidant activity.
Keywords:
2’,7’-dichlorofluorescein; Fenton system; liver cells; malondialdehyde (MDA); selenium.
MeSH terms
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Animals
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Antioxidants / chemical synthesis
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Antioxidants / chemistry
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Antioxidants / pharmacology*
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Cells, Cultured
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Hepatocytes / drug effects
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Hepatocytes / metabolism
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Macromolecular Substances / chemical synthesis
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Macromolecular Substances / chemistry
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Macromolecular Substances / pharmacology
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Male
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Models, Biological
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Nanostructures / chemistry
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Oxidative Stress / drug effects*
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Pyrans / chemical synthesis
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Pyrans / chemistry
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Pyrans / pharmacology
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Rats
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Rats, Wistar
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Reactive Oxygen Species / metabolism
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Selenium Compounds / chemical synthesis
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Selenium Compounds / chemistry
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Selenium Compounds / pharmacology
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Terpenes / chemistry
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Terpenes / pharmacology
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beta-Cyclodextrins / chemical synthesis
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beta-Cyclodextrins / chemistry
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beta-Cyclodextrins / pharmacology*
Substances
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Antioxidants
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Macromolecular Substances
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Pyrans
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Reactive Oxygen Species
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Selenium Compounds
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Terpenes
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beta-Cyclodextrins
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clathric acid