Airway Pressure Release Ventilation Mode Improves Circulatory and Respiratory Function in Patients After Cardiopulmonary Bypass, a Randomized Trial

Huiqing Ge; Ling Lin; Ying Xu; Peifeng Xu; Kailiang Duan; Qing Pan; Kejing Ying

doi:10.3389/fphys.2021.684927

Airway Pressure Release Ventilation Mode Improves Circulatory and Respiratory Function in Patients After Cardiopulmonary Bypass, a Randomized Trial

Front Physiol. 2021 Jun 3:12:684927. doi: 10.3389/fphys.2021.684927. eCollection 2021.

Authors

Huiqing Ge¹, Ling Lin², Ying Xu¹, Peifeng Xu¹, Kailiang Duan¹, Qing Pan³, Kejing Ying⁴

Affiliations

¹ Department of Respiratory Care, Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
² Department of Critical Care Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
³ College of Information Engineering, Zhejiang University of Technology, Hangzhou, China.
⁴ Department of Respiratory and Critical Care, Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Abstract

Importance: Postoperative pulmonary complications and cardiovascular complications are major causes of morbidity, mortality, and resource utilization in cardiac surgery patients.

Objectives: To investigate the effects of airway pressure release ventilation (APRV) on respiration and hemodynamics in post cardiac surgery patients.

Main outcomes and measures: A single-center randomized control trial was performed. In total, 138 patients undergoing cardiopulmonary bypass were prospectively screened. Ultimately 39 patients met the inclusion criteria and were randomized into two groups: 19 patients were managed with pressure control ventilation (PCV) and 20 patients were managed with APRV. Respiratory mechanics after 4 h, hemodynamics within the first day, and Chest radiograph score (CRS) and blood gasses within the first three days were recorded and compared.

Results: A higher cardiac index (3.1 ± 0.7 vs. 2.8 ± 0.8 L⋅min^-1⋅m²; p < 0.05), and shock volume index (35.4 ± 9.2 vs. 33.1 ± 9.7 ml m^-2; p < 0.05) were also observed in the APRV group after 4 h as well as within the first day (p < 0.05). Compared to the PCV group, the PaO2/FiO₂ was significantly higher after 4 h in patients of APRV group (340 ± 97 vs. 301 ± 82, p < 0.05) and within the first three days (p < 0.05) in the APRV group. CRS revealed less overall lung injury in the APRV group (p < 0.001). The duration of mechanical ventilation and ICU length of stay were not significantly (p = 0.248 and 0.424, respectively).

Conclusions and relevance: Compared to PCV, APRV may be associated with increased cardiac output improved oxygenation, and decreased lung injury in postoperative cardiac surgery patients.

Keywords: airway pressure release ventilation; cardiopulmonary bypass; circulatory function; mechanical ventilation; respiratory function.