Getting stressed over topoisomerase I poisons

Cell Chem Biol. 2021 Jun 17;28(6):743-745. doi: 10.1016/j.chembiol.2021.04.015.

Abstract

Topoisomerase I is the target for a number of widely prescribed anticancer drugs that are based on camptothecin. In this issue of Cell Chemical Biology, Flor et al. (2020) demonstrate that the cellular response to camptothecin is mediated by lipid-derived electrophiles that are generated as a result of drug-induced oxidative stress.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Camptothecin / pharmacology
  • DNA Topoisomerases, Type I* / metabolism
  • Poisons*
  • Topoisomerase I Inhibitors

Substances

  • Poisons
  • Topoisomerase I Inhibitors
  • DNA Topoisomerases, Type I
  • Camptothecin