Renal Injuries in Primary Aldosteronism: Quantitative Histopathological Analysis of 19 Patients With Primary Adosteronism

Hiroko Ogata; Yuto Yamazaki; Yuta Tezuka; Xin Gao; Kei Omata; Yoshikiyo Ono; Yoshihide Kawasaki; Tomoaki Tanaka; Hidekazu Nagano; Norio Wada; Yutaka Oki; Akira Ikeya; Kenji Oki; Yoshiyu Takeda; Mitsuhiro Kometani; Kazunori Kageyama; Ken Terui; Celso E Gomez-Sanchez; Shujun Liu; Ryo Morimoto; Kensuke Joh; Hiroshi Sato; Mariko Miyazaki; Akihiro Ito; Yoichi Arai; Yasuhiro Nakamura; Sadayoshi Ito; Fumitoshi Satoh; Hironobu Sasano

doi:10.1161/HYPERTENSIONAHA.121.17436

Renal Injuries in Primary Aldosteronism: Quantitative Histopathological Analysis of 19 Patients With Primary Adosteronism

Hypertension. 2021 Aug;78(2):411-421. doi: 10.1161/HYPERTENSIONAHA.121.17436. Epub 2021 Jun 14.

Authors

Hiroko Ogata¹, Yuto Yamazaki^{1

2}, Yuta Tezuka^{3

4}, Xin Gao¹, Kei Omata^{2

3}, Yoshikiyo Ono^{2

3}, Yoshihide Kawasaki⁵, Tomoaki Tanaka⁶, Hidekazu Nagano⁶, Norio Wada⁷, Yutaka Oki⁸, Akira Ikeya⁸, Kenji Oki⁹, Yoshiyu Takeda¹⁰, Mitsuhiro Kometani¹⁰, Kazunori Kageyama¹¹, Ken Terui¹¹, Celso E Gomez-Sanchez^{12

13}, Shujun Liu¹⁴, Ryo Morimoto³, Kensuke Joh¹⁵, Hiroshi Sato¹⁶, Mariko Miyazaki³, Akihiro Ito⁵, Yoichi Arai⁵, Yasuhiro Nakamura¹⁷, Sadayoshi Ito³, Fumitoshi Satoh^{2

3}, Hironobu Sasano¹

Affiliations

¹ From the Department of Pathology (H.O., Y.Y., X.G., H. Sasano), Tohoku University Graduate School of Medicine, Sendai, Japan.
² Division of Clinical Hypertension, Endocrinology and Metabolism (Y. Tezuka, K. Omata, Y. Ono, F.S.), Tohoku University Graduate School of Medicine, Sendai, Japan.
³ Division of Nephrology, Endocrinology, and Vascular Medicine (Y. Tezuka, K. Omata, Y. Ono, R.M., M.M., S.I., F.S.), Tohoku University Hospital, Sendai, Japan.
⁴ Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor (Y. Tezuka).
⁵ Division of Urology (Y.K., A. Ito, Y.A.), Tohoku University Hospital, Sendai, Japan.
⁶ Department of Molecular diagnosis, Chiba University Graduate School of Medicine, Japan (T.T., H.N.).
⁷ Department of Diabetes and Endocrinology, Sapporo City General Hospital, Japan (N.W.).
⁸ Department of Endocrinology and Metabolism, Hamamatsu University School of Medicine, Shizuoka, Japan (Y. Oki, A. Ikeya).
⁹ Department of Molecular and Internal Medicine, Graduate School of Biochemical and Health Sciences, Hiroshima University Hospital, Japan (K. Oki).
¹⁰ Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Japan (Y. Takeda, M.K.).
¹¹ Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, Japan (K.K., K.T.).
¹² Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Center, Jackson (C.E.G.-S.).
¹³ Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Center, Jackson, MS (C.E.G.-S.).
¹⁴ Department of Nephrology, The Second Hospital of Jilin University, Changchun, China (S.L.).
¹⁵ Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan (K.J.).
¹⁶ Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Faculty of Pharmaceutical Sciences, Sendai, Japan (H. Sato).
¹⁷ Division of Pathology, Faculty of medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan (Y.N.).

Abstract

[Figure: see text].

Keywords: 11βHSD; aldosterone; histopathology; hypertension; mineralocorticoid receptor; renin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Essential Hypertension / pathology
Female
Humans
Hyperaldosteronism / pathology*
Kidney / pathology*
Male
Middle Aged
Muscle, Smooth, Vascular / pathology
Retrospective Studies

Abstract

Publication types

MeSH terms

Grants and funding