Reperfused vs. nonreperfused myocardial infarction: when to use which model

Merry L Lindsey; Lisandra E de Castro Brás; Kristine Y DeLeon-Pennell; Nikolaos G Frangogiannis; Ganesh V Halade; Caitlin C O'Meara; Francis G Spinale; Zamaneh Kassiri; Jonathan A Kirk; Petra Kleinbongard; Crystal M Ripplinger; Keith R Brunt

doi:10.1152/ajpheart.00234.2021

Reperfused vs. nonreperfused myocardial infarction: when to use which model

Am J Physiol Heart Circ Physiol. 2021 Jul 1;321(1):H208-H213. doi: 10.1152/ajpheart.00234.2021. Epub 2021 Jun 11.

Authors

Affiliations

¹ Department of Cellular and Integrative Physiology, Center for Heart and Vascular Research, University of Nebraska Medical Center, Omaha, Nebraska.
² Research Service, Nebraska-Western Iowa Health Care System, Omaha, Nebraska.
³ Department of Physiology, The Brody School of Medicine, East Carolina University, Greenville, North Carolina.
⁴ Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.
⁵ Research Service, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina.
⁶ Department of Medicine (Cardiology), The Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, New York.
⁷ Division of Cardiovascular Sciences, Department of Medicine, University of South Florida, Tampa, Florida.
⁸ Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
⁹ Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
¹⁰ Genomics Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
¹¹ University of South Carolina School of Medicine and Columbia Veteran Affairs HealthCare System, Columbia, South Carolina.
¹² Department of Physiology, Cardiovascular Research Center, University of Alberta, Edmonton, Alberta, Canada.
¹³ Department of Cell and Molecular Physiology, Loyola University Chicago Stritch School of Medicine, Chicago, Illinois.
¹⁴ Institute for Pathophysiology, West German Heart and Vascular Center, University of Essen Medical School, Essen, Germany.
¹⁵ Department of Pharmacology, UC Davis School of Medicine, Davis, California.
¹⁶ Department of Pharmacology, Faculty of Medicine, Dalhousie University, Saint John, New Brunswick, Canada.

Abstract

There is a lack of understanding in the cardiac remodeling field regarding the use of nonreperfused myocardial infarction (MI) and reperfused MI in animal models of MI. This Perspectives summarizes the consensus of the authors regarding how to select the optimum model for your experiments and is a part of ongoing efforts to establish rigor and reproducibility in cardiac physiology research.

Keywords: cardiac; cardiomyocyte; ischemia-reperfusion; myocardial infarction; rigor and reproducibility.

Publication types

Editorial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Disease Models, Animal
Heart
Myocardial Infarction*
Myocardial Ischemia*
Myocardial Reperfusion*

Abstract

Publication types

MeSH terms

Grants and funding