Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis

Rahul Y Mahida; Aaron Scott; Dhruv Parekh; Sebastian T Lugg; Rowan S Hardy; Gareth G Lavery; Michael A Matthay; Babu Naidu; Gavin D Perkins; David R Thickett

doi:10.1183/13993003.00829-2021

Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis

Eur Respir J. 2021 Sep 9;58(3):2100829. doi: 10.1183/13993003.00829-2021. Print 2021 Sep.

Authors

Rahul Y Mahida^{1

2}, Aaron Scott^{3

2}, Dhruv Parekh³, Sebastian T Lugg³, Rowan S Hardy⁴, Gareth G Lavery⁴, Michael A Matthay⁵, Babu Naidu³, Gavin D Perkins^{6

7}, David R Thickett^{3

7}

Affiliations

¹ Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK r.mahida@bham.ac.uk.
² Joint first authors.
³ Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
⁴ Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
⁵ Dept of Medicine, and Dept of Anaesthesia, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
⁶ Emergency, Pre-hospital, Perioperative and Critical Care Group, Warwick Medical School, University of Warwick, Warwick, UK.
⁷ Joint senior authors.

Abstract

ARDS patients have decreased alveolar macrophage efferocytosis, which is associated with increased alveolar inflammation, and may contribute to worse clinical outcomes, including mortality. Upregulation of efferocytosis may offer a therapeutic strategy. https://bit.ly/2Q7REdM

Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis

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Abstract

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Grants and funding