Activation of Autophagic Flux Blunts Cardiac Ischemia/Reperfusion Injury

Circ Res. 2021 Jul 23;129(3):435-450. doi: 10.1161/CIRCRESAHA.120.318601. Epub 2021 Jun 11.

Abstract

[Figure: see text].

Keywords: autophagy; cardiomyopathies; histone deacetylases; ischemia; reperfusion.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autophagy*
  • Autophagy-Related Protein 7 / genetics
  • Autophagy-Related Protein 7 / metabolism
  • Beclin-1 / pharmacology*
  • Beclin-1 / therapeutic use
  • Cells, Cultured
  • Mice
  • Mice, Inbred C57BL
  • Myocardial Contraction
  • Myocardial Reperfusion Injury / drug therapy
  • Myocardial Reperfusion Injury / metabolism*
  • Myocytes, Cardiac / drug effects
  • Myocytes, Cardiac / metabolism*
  • Myocytes, Cardiac / physiology
  • Rats
  • Rats, Sprague-Dawley
  • Reactive Oxygen Species / metabolism
  • Recombinant Proteins / pharmacology
  • Recombinant Proteins / therapeutic use

Substances

  • Atg7 protein, mouse
  • Beclin-1
  • Reactive Oxygen Species
  • Recombinant Proteins
  • Autophagy-Related Protein 7