A Variant Noncoding Region Regulates Prrx1 and Predisposes to Atrial Arrhythmias

Circ Res. 2021 Jul 23;129(3):420-434. doi: 10.1161/CIRCRESAHA.121.319146. Epub 2021 Jun 7.

Abstract

[Figure: see text].

Keywords: atrial fibrillation; chromatin; electrophysiology; gene expression; transcription factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials
  • Animals
  • Atrial Fibrillation / genetics*
  • Atrial Fibrillation / metabolism
  • Cells, Cultured
  • Genetic Loci
  • Homeodomain Proteins / genetics*
  • Homeodomain Proteins / metabolism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mutation
  • Myocytes, Cardiac / metabolism
  • Myocytes, Cardiac / physiology
  • Myosin Heavy Chains / genetics
  • Myosin Heavy Chains / metabolism
  • Protein Kinases / genetics
  • Protein Kinases / metabolism
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism
  • Regulatory Sequences, Nucleic Acid*
  • Troponin T / genetics
  • Troponin T / metabolism
  • Up-Regulation

Substances

  • Homeodomain Proteins
  • Myh6 protein, mouse
  • Prrx1 protein, mouse
  • RBM20 protein, mouse
  • RNA-Binding Proteins
  • Tnnt2 protein, mouse
  • Troponin T
  • Protein Kinases
  • titin protein, mouse
  • Myosin Heavy Chains