Generation of induced pluripotent stem cell line (ZZUi028-A) from a 52-year-old Chinese Han healthy female individual

Yanlin Wang; Zhuoya Wang; Huifang Sun; Qi Zhang; Jing Yang; Yutao Liu; Han Liu; Changhe Shi; Rui Zhang; Yuming Xu

doi:10.1016/j.scr.2021.102381

Generation of induced pluripotent stem cell line (ZZUi028-A) from a 52-year-old Chinese Han healthy female individual

Stem Cell Res. 2021 May:53:102381. doi: 10.1016/j.scr.2021.102381. Epub 2021 May 5.

Authors

Yanlin Wang¹, Zhuoya Wang¹, Huifang Sun², Qi Zhang², Jing Yang¹, Yutao Liu¹, Han Liu¹, Changhe Shi¹, Rui Zhang³, Yuming Xu⁴

Affiliations

¹ Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
² Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Academy of Medical Science, Zhengzhou University, Zhengzhou, Henan 450001, China.
³ Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: ruizhangyy@126.com.
⁴ Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: xuyuming@zzu.edu.cn.

PMID: 34088010
DOI: 10.1016/j.scr.2021.102381

Abstract

Skin fibroblasts were donated by a healthy 52-year-old Han Chinese woman. The induced pluripotent stem cell (iPSC) line was constructed using an episomal reprogramming method that made the generated iPSCs integration-free. This iPSC line expressed the common pluripotency markers, could be differentiated into three germ layers, and showed normal karyotype in vivo. The iPSC line can be used to generate different cell types, which could be used as a control in drug development and studies on pathological mechanisms.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers
Cell Differentiation
China
Female
Germ Layers
Humans
Induced Pluripotent Stem Cells*
Middle Aged

Substances

Biomarkers