The performance of the SARS-CoV-2 RT-PCR test as a tool for detecting SARS-CoV-2 infection in the population

Andreas Stang; Johannes Robers; Birte Schonert; Karl-Heinz Jöckel; Angela Spelsberg; Ulrich Keil; Paul Cullen

doi:10.1016/j.jinf.2021.05.022

The performance of the SARS-CoV-2 RT-PCR test as a tool for detecting SARS-CoV-2 infection in the population

J Infect. 2021 Aug;83(2):237-279. doi: 10.1016/j.jinf.2021.05.022. Epub 2021 Jun 1.

Authors

Andreas Stang¹, Johannes Robers², Birte Schonert³, Karl-Heinz Jöckel⁴, Angela Spelsberg⁵, Ulrich Keil⁶, Paul Cullen⁷

Affiliations

¹ Institute of Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Germany; School of Public Health, Department of Epidemiology, Boston University, Boston, USA. Electronic address: imibe.dir@uk-essen.de.
² MVZ Labor Münster Hafenweg GmbH, Hafenweg 9-11; 48155, Münster, Germany. Electronic address: johannes.robers@labor-muenster.de.
³ MVZ Labor Münster Hafenweg GmbH, Hafenweg 9-11; 48155 Münster, Germany. Electronic address: birte.schonert@labor-muenster.de.
⁴ Institute of Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Germany. Electronic address: k-h.joeckel@uk-essen.de.
⁵ Tumorzentrum Aachen e.V., Pauwelsstraße 30, 52074 Aachen, Germany. Electronic address: spelsberg@tuzac.de.
⁶ Institute of Epidemiology and Social Medicine, University of Münster, Albert Schweitzer Campus 1, 48149 Münster. Electronic address: keilu@uni-muenster.de.
⁷ MVZ Labor Münster Hafenweg GmbH, Hafenweg 9-11; 48155, Münster, Germany. Electronic address: p.cullen@labor-muenster.de.

No abstract available

Keywords: Covid-19; SARS-CoV-2 real time-polymerase chain reaction; cycle-threshold value; infectious potential; laboratory quality assurance; screening.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

COVID-19*
Clinical Laboratory Techniques
Humans
RNA, Viral / genetics
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
SARS-CoV-2*
Sensitivity and Specificity

Substances

RNA, Viral