MYC/BCL2/BCL6 triple hit and TP53 deletion in a case of high-grade B cell lymphoma receiving CAR T cell immunotherapy

J Immunother Cancer. 2021 Jun;9(6):e002029. doi: 10.1136/jitc-2020-002029.

Authors

Jiachen Wang¹, Zhen Shang¹, Jue Wang¹, Jinhuan Xu¹, Weigang Li², Yuqi Guan¹, Li Yang¹, Wei Zhang¹, Kefeng Shen¹, Meilan Zhang¹, Jin Wang¹, Liting Chen¹, Qinlu Li¹, Cheng He¹, Na Wang¹, Liang Huang¹, Yi Xiao³, Min Xiao³, Jianfeng Zhou¹

Affiliations

¹ Department of Hematology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
² Department of Orthopedics, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
³ Department of Hematology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China xiaomin@tjh.tjmu.edu.cn yixiao@tjh.tjmu.edu.cn.

No abstract available

Keywords: adoptive; case reports; hematologic neoplasms; immunotherapy.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antigenic Drift and Shift
Disease Progression
Gene Deletion
Genetic Variation*
Humans
Immunotherapy, Adoptive / methods*
Lymphoma, Large B-Cell, Diffuse / genetics*
Lymphoma, Large B-Cell, Diffuse / immunology
Lymphoma, Large B-Cell, Diffuse / therapy*
Male
Proto-Oncogene Proteins c-bcl-2 / genetics
Proto-Oncogene Proteins c-bcl-6 / genetics
Proto-Oncogene Proteins c-myc / genetics
Receptors, Chimeric Antigen / immunology
Tumor Suppressor Protein p53 / genetics

Substances

BCL2 protein, human
BCL6 protein, human
MYC protein, human
Proto-Oncogene Proteins c-bcl-2
Proto-Oncogene Proteins c-bcl-6
Proto-Oncogene Proteins c-myc
Receptors, Chimeric Antigen
TP53 protein, human
Tumor Suppressor Protein p53