Molecular Imaging of Inflammation and Fibrosis in Pressure Overload Heart Failure

Circ Res. 2021 Jul 23;129(3):369-382. doi: 10.1161/CIRCRESAHA.120.318539. Epub 2021 Jun 2.

Authors

Aylina Glasenapp^{1

2}, Katja Derlin², Marcel Gutberlet², Annika Hess¹, Tobias L Ross¹, Hans-Jürgen Wester³, Frank M Bengel¹, James T Thackeray¹

Affiliations

¹ Department of Nuclear Medicine (A.G., A.H., T.L.R., F.M.B., J.T.T.).
² Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Germany (A.G., K.D., M.G.).
³ Technical University of Munich, Radiopharmaceutical Chemistry, Germany (H.-J.W.).

PMID: 34074134
DOI: 10.1161/CIRCRESAHA.120.318539

Abstract

[Figure: see text].

Keywords: fibrosis; heart failure; inflammation; magnetic resonance imaging; positron emission tomography.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Coordination Complexes / pharmacokinetics
Fibrosis
Heart Failure / diagnostic imaging*
Macrophages / metabolism*
Magnetic Resonance Imaging*
Male
Mice
Mice, Inbred C57BL
Myocardium / metabolism
Myocardium / pathology
Peptides, Cyclic / pharmacokinetics
Positron-Emission Tomography*
Radiopharmaceuticals / pharmacokinetics
Receptors, CXCR4 / metabolism

Substances

68Ga-pentixafor
CXCR4 protein, mouse
Coordination Complexes
Peptides, Cyclic
Radiopharmaceuticals
Receptors, CXCR4