Antireflux and Endoscopic Therapies for Barrett Esophagus and Superficial Esophageal Neoplasia

Ekaterina Fedorova; Thomas J Watson

doi:10.1016/j.suc.2021.03.002

Antireflux and Endoscopic Therapies for Barrett Esophagus and Superficial Esophageal Neoplasia

Surg Clin North Am. 2021 Jun;101(3):391-403. doi: 10.1016/j.suc.2021.03.002.

Authors

Ekaterina Fedorova¹, Thomas J Watson²

Affiliations

¹ MedStar Franklin Square Medical Center, 9000 Franklin Square Drive, Department of Surgery, Baltimore, MD 21237, USA.
² MedStar Georgetown University Hospital, 3800 Reservoir Rd, NW, 4PHC Department of Surgery, Washington, DC 20007, USA. Electronic address: tjwmd9@gmail.com.

PMID: 34048760
DOI: 10.1016/j.suc.2021.03.002

Abstract

Barrett esophagus (BE), defined as intestinal metaplasia of the distal esophageal mucosa, typically results from chronic gastroesophageal reflux disease and is the only known precursor of esophageal adenocarcinoma. The standard of care for the management of early esophageal neoplasia in the setting of BE has changed drastically over the past 15 years. Further investigation into diagnostic and therapeutic adjuncts will continue to improve our ability to control or cure BE before its advancement to a life-threatening malignancy.

Keywords: Barrett esophagus; Endoscopic resection; Esophageal adenocarcinoma; Gastroesophageal reflux disease; Radiofrequency ablation.

Publication types

Review

MeSH terms

Ablation Techniques
Adenocarcinoma / pathology
Adenocarcinoma / prevention & control*
Barrett Esophagus / etiology
Barrett Esophagus / pathology
Barrett Esophagus / surgery*
Disease Progression
Esophageal Neoplasms / pathology
Esophageal Neoplasms / prevention & control*
Esophagoscopy / methods*
Fundoplication*
Gastroesophageal Reflux / complications
Gastroesophageal Reflux / therapy*
Humans
Precancerous Conditions / pathology
Precancerous Conditions / surgery*
Proton Pump Inhibitors / therapeutic use*

Substances

Proton Pump Inhibitors

Supplementary concepts

Adenocarcinoma Of Esophagus