Hunger brings down the tumor fort

Anastasia-Maria Zavitsanou; Thales Papagiannakopoulos

doi:10.1016/j.tcb.2021.05.005

Hunger brings down the tumor fort

Trends Cell Biol. 2021 Aug;31(8):616-617. doi: 10.1016/j.tcb.2021.05.005. Epub 2021 May 22.

Authors

Anastasia-Maria Zavitsanou¹, Thales Papagiannakopoulos²

Affiliations

¹ Department of Pathology, New York University Grossman School of Medicine, 550 First Avenue, New York, NY 10016, USA; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, 550 First Avenue, New York, NY 10016, USA.
² Department of Pathology, New York University Grossman School of Medicine, 550 First Avenue, New York, NY 10016, USA; Perlmutter Cancer Center, New York University Grossman School of Medicine, 550 First Avenue, New York, NY 10016, USA. Electronic address: papagt01@nyumc.org.

PMID: 34034933
DOI: 10.1016/j.tcb.2021.05.005

Abstract

In a recent article published in Molecular Cell, Dai et al. demonstrate that energy stress induced by a ketogenic diet or fasting can enhance checkpoint blockade therapy. Energy stress promotes lysosome-mediated degradation of the immunoinhibitory ligand programmed death-ligand 1 (PDL1) and upregulation of tumor interferon (IFN) responses.

Keywords: AMPK; PDL1; immunotherapy; ketogenic diet.

MeSH terms

Humans
Hunger*
Interferons
Neoplasms*

Substances

Interferons