Design concepts for DNA-encoded library synthesis

Y Zhang; M A Clark

doi:10.1016/j.bmc.2021.116189

Design concepts for DNA-encoded library synthesis

Bioorg Med Chem. 2021 Jul 1:41:116189. doi: 10.1016/j.bmc.2021.116189. Epub 2021 May 1.

Authors

Y Zhang¹, M A Clark²

Affiliations

¹ X-Chem Inc., 100 Beaver Street, Waltham, MA 02453, USA.
² X-Chem Inc., 100 Beaver Street, Waltham, MA 02453, USA. Electronic address: mclark@x-chemrx.com.

PMID: 34034150
DOI: 10.1016/j.bmc.2021.116189

Abstract

An approach of building block (BB) inclusivity and atom efficient library schemes deliver the quality and diversity of DNA-encoded libraries best suited for small molecule drug discovery. In this Perspective, we offer key learnings in DEL design from a decade's worth of DEL-driven screening.

Keywords: DNA-Encoded Library; Medicinal Chemistry.

MeSH terms

Combinatorial Chemistry Techniques
DNA / chemistry*
DNA Replication
Drug Design*
Drug Discovery*
Gene Library*
Small Molecule Libraries*

Substances

Small Molecule Libraries
DNA