Clinical aspects and prognosis of patients with inflammatory bowel disease associated with autoimmune liver diseases

Gastroenterol Hepatol. 2022 Feb;45(2):83-90. doi: 10.1016/j.gastrohep.2021.03.011. Epub 2021 May 20.
[Article in English, Spanish]

Abstract

Background and aims: Inflammatory bowel diseases (IBD) are chronic conditions that may be accompanied by autoimmune liver disease (AILD), most commonly primary sclerosing cholangitis (PSC). The objective of this study was to evaluate the behaviour of patients with IBD associated with AILD and compare a PSC group with a non-PSC group.

Methods: Medical records of patients with IBD associated with PSC, autoimmune cholangitis, primary biliary cholangitis, small-duct PSC, autoimmune hepatitis (AIH) and overlapping syndromes were assessed.

Results: Fifty-four patients were included: 48 (88.9%) had ulcerative colitis and six (11.1%) had Crohn's disease; 35 (64.8%) had PSC and 19 (35.2%) did not have PSC. There was no difference in outcomes (surgical treatment for IBD, liver transplantation or death) between the groups. Time since the diagnosis of IBD was associated with surgical treatment of IBD (p=0.041; OR: 1.139, 95% CI: 1.006-1.255). Time since the diagnosis of AILD (p=0.003; OR: 1.259, 95% CI: 1.1-1.396), as well as portal hypertension at diagnosis (p=0.014; OR: 18.22, 95% CI: 1.815-182.96), were associated with liver transplantation. In addition, previous diagnosis of AIH was associated with de novo IBD (p=0.012; OR: 7.1, 95% CI: 1.215-42.43).

Conclusion: Both groups had similar disease behaviour. A longer time since the diagnosis of IBD increased the risk for surgical treatment (13.9%/year). A 25.9%/year increase in liver transplantation was observed after the diagnosis of AILD, which was increased 18.22 times by the presence of portal hypertension. In addition, the diagnosis of AIH was associated with an increase in the number of diagnoses of de novo IBD (7.1).

Keywords: Autoimmune hepatitis; Colangitis esclerosante primaria; Colitis ulcerosa; Crohn's disease; Enfermedad de Crohn; Hepatitis autoinmune; Liver transplant; Primary sclerosing cholangitis; Trasplante de hígado; Ulcerative colitis.

Publication types

  • Observational Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cholangitis / complications
  • Cholangitis / epidemiology
  • Cholangitis, Sclerosing* / complications
  • Cholangitis, Sclerosing* / epidemiology
  • Colitis, Ulcerative* / complications
  • Colitis, Ulcerative* / diagnosis
  • Colitis, Ulcerative* / epidemiology
  • Colitis, Ulcerative* / surgery
  • Crohn Disease* / complications
  • Crohn Disease* / diagnosis
  • Crohn Disease* / epidemiology
  • Crohn Disease* / surgery
  • Disease Progression
  • Female
  • Hepatitis, Autoimmune* / complications
  • Hepatitis, Autoimmune* / epidemiology
  • Humans
  • Hypertension, Portal / complications
  • Liver Cirrhosis, Biliary / complications
  • Liver Diseases* / complications
  • Liver Diseases* / epidemiology
  • Liver Transplantation / statistics & numerical data
  • Male
  • Middle Aged
  • Prognosis
  • Retrospective Studies
  • Time Factors
  • Young Adult