Prevalence of serological markers of hepatitis B in inflammatory bowel disease - Experience from a tertiary care centre in South India

Trop Doct. 2021 Jul;51(3):326-331. doi: 10.1177/00494755211015571. Epub 2021 May 21.

Abstract

Inflammatory bowel disease patients are at risk of hepatitis B infection. Data on this prevalence from South Asia are limited. We conducted a prospective study comprising of 76 inflammatory bowel disease patients between October 2013 and August 2014. Prevalence of hepatitis B surface antigen in inflammatory bowel disease, ulcerative colitis and Crohn's disease patients were 2.6%, 2.4% and 3% respectively and that of markers of hepatitis B exposure (hepatitis B surface antigen /hepatitis B core antibody) were 11.8%, 14.3% and 9.1% respectively. Risk factors found significantly more common in those positive for viral markers compared to those negative were age, non-inflammatory bowel disease related surgery and hospital admission. Only 7(9.2%) had completed hepatitis B vaccination. There is a need to create awareness among physicians regarding the importance of hepatitis B screening and vaccination in inflammatory bowel disease patients.

Keywords: Inflammatory bowel disease; hepatitis B; serology; vaccination.

MeSH terms

  • Biomarkers
  • Hepatitis B / diagnosis
  • Hepatitis B / epidemiology*
  • Hepatitis B Surface Antigens
  • Humans
  • India / epidemiology
  • Inflammatory Bowel Diseases / diagnosis
  • Inflammatory Bowel Diseases / epidemiology*
  • Prevalence
  • Prospective Studies
  • Tertiary Care Centers

Substances

  • Biomarkers
  • Hepatitis B Surface Antigens