Molecular Mechanisms of miR-1271 Dysregulation in Human Cancer

DNA Cell Biol. 2021 Jun;40(6):740-747. doi: 10.1089/dna.2021.0100. Epub 2021 May 20.

Abstract

MicroRNA is a small noncoding RNA that plays a role in regulating gene expression. miR-1271 is a tumor suppressor microRNA, which is related to the biological changes of many cancers. miR-1271 is considered a biomarker with a potential prognosis and high therapeutic value in tumors. Besides, the expression of miR-1271 is also regulated by many factors. In this study, we summarize the role of miR-1271 in tumors, focusing on the molecular mechanisms of the target genes of miR-1271. Our review will provide a comprehensive understanding of miR-1271 in tumors, as well as ideas for subsequent tumor research related to miR-1271.

Keywords: biomarker; cancer; dysregulation; miR-1271; prognosis.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / physiology
  • Gene Expression Regulation, Neoplastic*
  • Genes, Tumor Suppressor*
  • Humans
  • MicroRNAs / physiology*
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Signal Transduction

Substances

  • Biomarkers, Tumor
  • MIRN1271 microRNA, human
  • MicroRNAs