Dual-energy CT in predicting Ki-67 expression in laryngeal squamous cell carcinoma

Peng Wang; Zuohua Tang; Zebin Xiao; Lingjie Wu; Rujian Hong; Fei Duan; Yuzhe Wang; Yang Zhan

doi:10.1016/j.ejrad.2021.109774

Dual-energy CT in predicting Ki-67 expression in laryngeal squamous cell carcinoma

Eur J Radiol. 2021 Jul:140:109774. doi: 10.1016/j.ejrad.2021.109774. Epub 2021 May 12.

Authors

Peng Wang¹, Zuohua Tang², Zebin Xiao³, Lingjie Wu⁴, Rujian Hong⁵, Fei Duan⁵, Yuzhe Wang⁵, Yang Zhan⁶

Affiliations

¹ Department of Radiology, Eye & ENT Hospital of Shanghai Medical School, Fudan University, Shanghai, 200031, PR China; Department of Radiology, The Affiliated Renmin Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212002, PR China.
² Department of Radiology, Eye & ENT Hospital of Shanghai Medical School, Fudan University, Shanghai, 200031, PR China. Electronic address: tzh518sunny@163.com.
³ Department of Radiology, Eye & ENT Hospital of Shanghai Medical School, Fudan University, Shanghai, 200031, PR China; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, 19104, USA.
⁴ Department of Otolaryngology, Eye & ENT Hospital of Shanghai Medical School, Fudan University, Shanghai, PR China.
⁵ Department of Radiology, Eye & ENT Hospital of Shanghai Medical School, Fudan University, Shanghai, 200031, PR China.
⁶ The Shanghai Institution of Medical Imaging, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China.

PMID: 34004427
DOI: 10.1016/j.ejrad.2021.109774

Abstract

Purpose: To investigate whether multiple dual-energy computed tomography (DECT) parameters can noninvasively predict the Ki-67 expression (associated with survival and prognosis) in laryngeal squamous cell carcinoma (LSCC).

Methods: Eighty-eight patients with histologically proven LSCC were retrospectively reviewed. Multiple DECT-derived parameters were measured and correlated with Ki-67 expression by Spearman correlation analysis. Comparisons of the DECT-derived parameters between tumors with low- and high-level expression of Ki-67 were made with the t-tests.

Results: The iodine concentration (IC), normalized IC (NIC), effective atomic number (Z_eff), 40-80 keV, and slope (k) values were positively correlated with Ki-67 expression (all p < 0.05, rho=0.367-0.548). Among all DECT-derived parameters, NIC value had the highest r value in correlation with Ki-67 expression. The IC, NIC, Z_eff, 40-80 keV, and slope (k) values were significantly higher in LSCC with high Ki-67 expression than in those with low Ki-67 expression (all p < 0.05).

Conclusions: Multiple DECT-derived parameters (IC, NIC, Z_eff, 40-80 keV, and slope (k)) can be used as predictors of survival and prognosis in LSCC, among which the NIC value is the strongest.

Keywords: Dual-energy computed tomography; Effective atomic number; Iodine concentration; Ki-67 expression; Laryngeal squamous cell carcinoma; Prognosis; Spectral attenuation curve.

MeSH terms

Head and Neck Neoplasms*
Humans
Iodine*
Ki-67 Antigen
Retrospective Studies
Squamous Cell Carcinoma of Head and Neck
Tomography, X-Ray Computed

Substances

Ki-67 Antigen
Iodine