Building unconventional G protein-coupled receptors, one block at a time

Pradipta Ghosh; Madhubanti Mullick

doi:10.1016/j.tips.2021.04.005

Building unconventional G protein-coupled receptors, one block at a time

Trends Pharmacol Sci. 2021 Jul;42(7):514-517. doi: 10.1016/j.tips.2021.04.005. Epub 2021 May 10.

Authors

Pradipta Ghosh¹, Madhubanti Mullick²

Affiliations

¹ Department of Medicine, University of California, San Diego, CA 92093, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, CA 92093, USA. Electronic address: prghosh@ucsd.edu.
² Department of Cellular and Molecular Medicine, University of California, San Diego, CA 92093, USA.

Abstract

The structure, function, and dynamics of canonical activation of heterotrimeric G proteins by the seven-transmembrane G protein-coupled receptors (GPCRs) have been illustrated in detail. However, emerging studies during the past decade have started to shed light on how the same G proteins may also be accessed and modulated by a diverse family of receptors that are not conventional GPCRs. Can we learn about common themes and variations in how cells assemble these atypical GPCRs?

Keywords: Frizzled; GPCRs; Toll-like receptors; growth factors; guanine-nucleotide exchange modulators (GEMs); integrins.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Heterotrimeric GTP-Binding Proteins* / metabolism
Receptors, G-Protein-Coupled / metabolism
Signal Transduction*

Substances

Receptors, G-Protein-Coupled
Heterotrimeric GTP-Binding Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding