The measurement properties of tests and tools used in cystic fibrosis studies: a systematic review

Charlie McLeod; Jamie Wood; Allison Tong; André Schultz; Richard Norman; Sherie Smith; Christopher C Blyth; Steve Webb; Alan R Smyth; Thomas L Snelling

doi:10.1183/16000617.0354-2020

The measurement properties of tests and tools used in cystic fibrosis studies: a systematic review

Eur Respir Rev. 2021 May 11;30(160):200354. doi: 10.1183/16000617.0354-2020. Print 2021 Jun 30.

Authors

Charlie McLeod^{1

2

3}, Jamie Wood⁴, Allison Tong^{5

6}, André Schultz^{7

8}, Richard Norman⁹, Sherie Smith¹⁰, Christopher C Blyth^{11

2

3

12}, Steve Webb^{13

14}, Alan R Smyth¹⁰, Thomas L Snelling^{5

15}

Affiliations

¹ Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, Australia charlie.mcleod@health.wa.gov.au.
² Division of Paediatrics, Faculty of Medicine, University of Western Australia, Nedlands, Australia.
³ Infectious Diseases Dept, Perth Children's Hospital, Nedlands, Australia.
⁴ Physiotherapy Dept, Sir Charles Gairdner Hospital, Nedlands, Australia.
⁵ Sydney School of Public Health, The University of Sydney, Sydney, Australia.
⁶ Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Australia.
⁷ Wal-yan Respiratory Research Centre, Telethon Kids Institute, University of Western Australia, Nedlands, Australia.
⁸ Dept of Respiratory and Sleep Medicine, Perth Children's Hospital, Nedlands, Australia.
⁹ School of Population Health, Curtin University, Bentley, Australia.
¹⁰ Evidence Based Child Health Group, University of Nottingham, Queens Medical Centre, Nottingham, UK.
¹¹ Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, Australia.
¹² Pathwest Laboratory Medicine WA, QEII Medical Centre, Nedlands, Australia.
¹³ St John of God Hospital, Subiaco, Australia.
¹⁴ School of Population Health and Preventive Medicine, Monash University, Melbourne, Australia.
¹⁵ Menzies School of Health Research, Royal Darwin Hospital Campus, Tiwi, Australia.

Abstract

There is no consensus on how best to measure responses to interventions among children and adults with cystic fibrosis (CF). We have systematically reviewed and summarised the characteristics and measurement properties of tests and tools that have been used to capture outcomes in studies among people with CF, including their reliability, validity and responsiveness. This review is intended to guide researchers when selecting tests or tools for measuring treatment effects in CF trials. A consensus set of these tests and tools could improve consistency in how outcomes are captured and thereby facilitate comparisons and synthesis of evidence across studies.

Publication types

Review
Systematic Review

MeSH terms

Adult
Child
Cystic Fibrosis* / diagnosis
Cystic Fibrosis* / therapy
Humans
Reproducibility of Results