The developing relations between networks of cortical myelin and neurophysiological connectivity

Marlee M Vandewouw; Benjamin A E Hunt; Justine Ziolkowski; Margot J Taylor

doi:10.1016/j.neuroimage.2021.118142

The developing relations between networks of cortical myelin and neurophysiological connectivity

Neuroimage. 2021 Aug 15:237:118142. doi: 10.1016/j.neuroimage.2021.118142. Epub 2021 May 2.

Authors

Marlee M Vandewouw¹, Benjamin A E Hunt², Justine Ziolkowski³, Margot J Taylor⁴

Affiliations

¹ Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 0A4, Canada; Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto M5G 0A4, Canada; Autism Research Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON M4G 1R8, Canada; Institute of Biomedical Engineering, University of Toronto, Toronto M5S 3G9, Canada. Electronic address: marlee.vandewouw@sickkids.ca.
² Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 0A4, Canada; Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto M5G 0A4, Canada.
³ Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto M5G 0A4, Canada.
⁴ Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 0A4, Canada; Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto M5G 0A4, Canada; Department of Psychology, University of Toronto, Toronto M5G 0A4 Canada; Department of Medical Imaging, University of Toronto, Toronto M5G 0A4, Canada.

PMID: 33951516
DOI: 10.1016/j.neuroimage.2021.118142

Abstract

Recent work identified that patterns of distributed brain regions sharing similar myeloarchitecture are related to underlying functional connectivity, demonstrating cortical myelin's plasticity to changes in functional demand. However, the changing relations between functional and structural architecture throughout child and adulthood are poorly understood. We show that structural covariance connectivity (T1-weighted/T2-weighted ratio) and functional connectivity (magnetoencephalography) exhibit nonlinear developmental changes. We then show significant relations between structural and functional connectivity, which have shared and distinct characteristics dependent on the neural oscillatory frequency. Increases in structure-function coupling are visible during the protracted myelination observed throughout childhood and adolescence and are followed by decreases near the onset of adulthood. Our work lays the foundation for understanding the mechanisms by which myeloarchitecture supports brain function, enabling future investigations into how clinical populations may deviate from normative patterns.

Keywords: Connectivity; Development; Magnetic resonance imaging; Magnetoencephalography; Myelin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Brain Waves* / physiology
Cerebral Cortex* / anatomy & histology
Cerebral Cortex* / diagnostic imaging
Cerebral Cortex* / physiology
Child
Child, Preschool
Connectome*
Female
Humans
Magnetic Resonance Imaging*
Magnetoencephalography*
Male
Middle Aged
Myelin Sheath* / physiology
Nerve Net* / anatomy & histology
Nerve Net* / diagnostic imaging
Nerve Net* / physiology
Young Adult

Abstract

Publication types

MeSH terms

Grants and funding