Update of Topical Interventions for Healing Diabetic Ulcers-A Systematic Review

Int J Low Extrem Wounds. 2023 Jun;22(2):222-234. doi: 10.1177/15347346211013189. Epub 2021 May 5.

Abstract

There are a variety of dressings for wound healing. For this reason, research can assist in the choice and proper use of the intervention. This current view of the effectiveness of dressing on diabetic foot ulcers (DFUs) in patients with type 2 diabetes mellitus. This study is a systematic review of clinical trials selected in 4 databases: PubMed, Scopus, Web of Science, and Cochrane. Studies without language restriction, published between 2009 and 2020, were included. The search resulted in the identification of 5651 articles, of which 58 met all inclusion criteria. Among these, 2 biomaterials (D-acellular dermal matrix and keratinocyte) and phenytoin were highlighted for achieving healing rates of 100% and 95.82% ± 2.22%, respectively. The literature presents several alternatives with different actions, cure rates, reduction rates, and varied cost benefits. The growth in the use of biomaterials for the treatment of DFU can be seen in this study.

Keywords: diabetes complications; diabetic foot; foot ulcer; wound healing.

Publication types

  • Systematic Review
  • Review

MeSH terms

  • Bandages, Hydrocolloid
  • Diabetes Mellitus, Type 2* / complications
  • Diabetic Foot* / drug therapy
  • Diabetic Foot* / therapy
  • Humans
  • Wound Healing