Bioactive sesterterpenoids from the fungus Penicillium roqueforti YJ-14

Jia-Peng Wang; Yan Shu; Rui Liu; Jun-Li Gan; Si-Ping Deng; Xue-Yun Cai; Jun-Tao Hu; Le Cai; Zhong-Tao Ding

doi:10.1016/j.phytochem.2021.112762

Bioactive sesterterpenoids from the fungus Penicillium roqueforti YJ-14

Phytochemistry. 2021 Jul:187:112762. doi: 10.1016/j.phytochem.2021.112762. Epub 2021 Apr 30.

Authors

Jia-Peng Wang¹, Yan Shu¹, Rui Liu¹, Jun-Li Gan¹, Si-Ping Deng¹, Xue-Yun Cai¹, Jun-Tao Hu¹, Le Cai², Zhong-Tao Ding³

Affiliations

¹ Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China.
² Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China. Electronic address: caile@ynu.edu.cn.
³ Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China. Electronic address: ztding@ynu.edu.cn.

PMID: 33940379
DOI: 10.1016/j.phytochem.2021.112762

Abstract

Seven previously undescribed sesterterpenes were characterized from Penicillium roqueforti YJ-14 by solid fermentation. Their structures were initially investigated in detail by spectroscopic analyses and HR-ESI-MS and were further confirmed by X-crystallography. In in vitro bioassays, compounds 1, 5 and 7 showed cytotoxic activity against the MCF-7 breast cancer cell line with IC₅₀ values of 7.98 ± 0.93, 6.42 ± 0.41 and 7.32 ± 0.18 μM, respectively. Compounds 5 and 7 displayed significant cytotoxicity against the A549 lung cancer cell line (IC₅₀ values of 4.83 ± 0.22 μM and 4.58 ± 0.85 μM, respectively). In addition, compound 5 showed an obvious inhibitory effect on nitric oxide production in LPS-activated RAW264.7 macrophages with an IC₅₀ value of 9.53 ± 0.16 μM.

Keywords: Anti-inflammatory; Cytotoxicity; Peniroquesine; Sesterterpenoid.

MeSH terms

Fungi
Humans
Macrophages
Nitric Oxide
Penicillium*
Sesterterpenes / pharmacology

Substances

Sesterterpenes
Nitric Oxide

Supplementary concepts

Penicillium roqueforti