The imitation game: How glioblastoma outmaneuvers immune attack

Cell. 2021 Apr 29;184(9):2278-2281. doi: 10.1016/j.cell.2021.04.008.

Abstract

Immune evasion and resistance to immunotherapy mark major roadblocks in treating glioblastoma, the deadliest form of brain cancer. In this issue of Cell, Gangoso et al. demonstrate that the immune microenvironment drives glioblastoma cells to hijack myeloid-characteristic transcriptional and epigenetic circuits as a mode of immune evasion.

Publication types

  • Comment

MeSH terms

  • Brain Neoplasms* / genetics
  • Brain Neoplasms* / therapy
  • Glioblastoma* / genetics
  • Glioblastoma* / therapy
  • Humans
  • Imitative Behavior
  • Immunotherapy
  • Tumor Microenvironment