Metastatic Neuroblastoma Presenting as a Submandibular Mass with Mandibular Bone Involvement in a Three-Year-Old Child

Asad Ullah; Atbin Doroodchi; Luis Velasquez Zarate; Samantha N Mattox; Taylor Sliker; Dorian K Willhite; Jaffar Khan; Harry C Owen; Surendra K Rajpurohit; Nikhil G Patel; Robyn M Hatley

doi:10.3390/ijerph18084157

Metastatic Neuroblastoma Presenting as a Submandibular Mass with Mandibular Bone Involvement in a Three-Year-Old Child

Int J Environ Res Public Health. 2021 Apr 14;18(8):4157. doi: 10.3390/ijerph18084157.

Affiliations

¹ Department of Pathology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
² Department of Surgery, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
³ Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
⁴ Department of Pathology, Indiana University, Bloomington, IN 47405, USA.
⁵ Georgia Cancer Center, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
⁶ Department of Pediatric Surgery, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.

Abstract

Although neuroblastoma is one of the most common extra-cranial tumors in the pediatric population, it is rarely seen as a metastasis to the mandibular bone. The following is a case report of a 3-year-old male who initially presented with a submandibular mass that was proven to be a poorly differentiated metastatic neuroblastoma through excisional biopsy. This report is one of the few case reports that demonstrates metastatic submandibular neuroblastoma with mandibular bone involvement in the pediatric population.

Keywords: ganglioneuroblastoma; malignancy; neoplasm; neuroblastoma; pediatric neck mass.

Publication types

Case Reports

MeSH terms

Biopsy
Cell Differentiation
Child
Child, Preschool
Humans
Male
Mandible / diagnostic imaging
Neoplasms, Second Primary*
Neuroblastoma* / diagnostic imaging