CLOVES Syndrome Diagnosis and Treatment in an Adult Patient

Ann Vasc Surg. 2021 Aug:75:533.e5-533.e9. doi: 10.1016/j.avsg.2021.03.044. Epub 2021 Apr 24.

Abstract

CLOVES syndrome is a rare, nonheritable sporadic overgrowth disorder. In the world 130-200 cases have been reported. This is the first case of CLOVES described in Portugal, which had been not been diagnosed for the last 36 years. With this paper, the authors look to highlight the clinical features of this syndrome so that it does not go unrecognized in daily practice. The authors also underline the efficacy and safety of sirolimus, and that this treatment should not be denied, even in adult patients.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Humans
  • Lipoma / diagnosis*
  • Lipoma / drug therapy*
  • MTOR Inhibitors / therapeutic use*
  • Musculoskeletal Abnormalities / diagnosis*
  • Musculoskeletal Abnormalities / drug therapy*
  • Nevus / diagnosis*
  • Nevus / drug therapy*
  • Sirolimus / therapeutic use*
  • Treatment Outcome
  • Vascular Malformations / diagnosis*
  • Vascular Malformations / drug therapy*

Substances

  • MTOR Inhibitors
  • Sirolimus

Supplementary concepts

  • Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi