Outcomes of curative-intent radiotherapy in non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD)

Radiother Oncol. 2021 Jul:160:78-81. doi: 10.1016/j.radonc.2021.04.014. Epub 2021 Apr 24.

Abstract

Outcomes of non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD n = 587) and interstitial lung disease (ILD n = 34) treated with curative-intent radiotherapy were retrospectively investigated. Presence of ILD but not decreased forced expiratory volume in 1-second correlated with poor overall survival. Increased breathlessness and oxygen requirements after radiotherapy were observed in severe/very severe COPD and ILD.

Keywords: COPD; FEV1; ILD; NSCLC; Radiotherapy; Survival.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Non-Small-Cell Lung* / complications
  • Carcinoma, Non-Small-Cell Lung* / radiotherapy
  • Humans
  • Lung Diseases, Interstitial* / etiology
  • Lung Neoplasms* / complications
  • Lung Neoplasms* / radiotherapy
  • Pulmonary Disease, Chronic Obstructive* / complications
  • Retrospective Studies