Application of big-data for epidemiological studies of refractive error

PLoS One. 2021 Apr 23;16(4):e0250468. doi: 10.1371/journal.pone.0250468. eCollection 2021.

Abstract

Purpose: To examine whether data sourced from electronic medical records (EMR) and a large industrial spectacle lens manufacturing database can estimate refractive error distribution within large populations as an alternative to typical population surveys of refractive error.

Subjects: A total of 555,528 patient visits from 28 Irish primary care optometry practices between the years 1980 and 2019 and 141,547,436 spectacle lens sales records from an international European lens manufacturer between the years 1998 and 2016.

Methods: Anonymized EMR data included demographic, refractive and visual acuity values. Anonymized spectacle lens data included refractive data. Spectacle lens data was separated into lenses containing an addition (ADD) and those without an addition (SV). The proportions of refractive errors from the EMR data and ADD lenses were compared to published results from the European Eye Epidemiology (E3) Consortium and the Gutenberg Health Study (GHS).

Results: Age and gender matched proportions of refractive error were comparable in the E3 data and the EMR data, with no significant difference in the overall refractive error distribution (χ2 = 527, p = 0.29, DoF = 510). EMR data provided a closer match to the E3 refractive error distribution by age than the ADD lens data. The ADD lens data, however, provided a closer approximation to the E3 data for total myopia prevalence than the GHS data, up to age 64.

Conclusions: The prevalence of refractive error within a population can be estimated using EMR data in the absence of population surveys. Industry derived sales data can also provide insights on the epidemiology of refractive errors in a population over certain age ranges. EMR and industrial data may therefore provide a fast and cost-effective surrogate measure of refractive error distribution that can be used for future health service planning purposes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Distribution
  • Aged
  • Big Data*
  • Contact Lenses
  • Data Management
  • Electronic Health Records
  • Epidemiologic Studies
  • Eyeglasses
  • Female
  • Humans
  • Ireland / epidemiology
  • Male
  • Middle Aged
  • Myopia / diagnosis
  • Myopia / epidemiology*
  • Myopia / pathology
  • Myopia / prevention & control
  • Refractive Errors / epidemiology*
  • Refractive Errors / pathology
  • Refractive Errors / prevention & control
  • Sex Distribution
  • Vision Tests
  • Visual Acuity / physiology*
  • Young Adult

Grants and funding

Arne Ohlendorf and Siegfried Wahl are employees of Carl Zeiss Vision International GmbH. These authors provided access to some of the data used in this study and reviewed the work before submission. The funder provided support in the form of salaries for authors [AO, SW], but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section.