A Rare Case of Diffuse Neurofibroma of the Scalp With Destructive Lesions Involving the Base of the Skull in a Patient With Neurofibromatosis Type 1

Hamza Maqsood; Muhammad Saim; Abdul Sattar Anjum; Shifa Younus

doi:10.7759/cureus.13930

A Rare Case of Diffuse Neurofibroma of the Scalp With Destructive Lesions Involving the Base of the Skull in a Patient With Neurofibromatosis Type 1

Cureus. 2021 Mar 16;13(3):e13930. doi: 10.7759/cureus.13930.

Authors

Hamza Maqsood¹, Muhammad Saim¹, Abdul Sattar Anjum², Shifa Younus³

Affiliations

¹ Cardiology, Nishtar Medical University, Multan, PAK.
² Radiology, Nishtar Medical University, Multan, PAK.
³ Medicine, Nishtar Medical University, Multan, PAK.

Abstract

Diffuse neurofibroma is a benign tumor of peripheral nerves. Ten percent of neurofibromatosis type 1 (NF-1) patients can develop diffuse neurofibroma. Here, we report a case of diffuse neurofibroma involving the base of the skull in a 50-years-old patient with NF-1. The patient presented with diffuse involvement of the scalp with soft and mobile masses. Radiological investigations revealed skull bone lesions. Aggressive osteolytic lesions involving the base of the skull were present. Surgical excision with the repairing of the defects was suggested but the patient refused the treatment. The diagnosis of calvarial defects in diffuse neurofibroma is challenging. Early diagnosis can help in better management of the patients.

Keywords: calvarial; neurofibroma; neurofibromatosis; osteolytic; skull defects.

Publication types

Case Reports