Evolution of the Human Cytokine Response from Acute Illness to Disease Resolution in SARS-Cov-2 Infection-Implications for Therapeutic Monitoring and Therapeutic Targets

George P Drewett; Ana Copaescu; Effie Mouhtouris; Natalie Hannan; Fiona James; Olivia Smibert; Natasha E Holmes; Jason A Trubiano

doi:10.1007/s10875-021-01039-x

Evolution of the Human Cytokine Response from Acute Illness to Disease Resolution in SARS-Cov-2 Infection-Implications for Therapeutic Monitoring and Therapeutic Targets

J Clin Immunol. 2021 Aug;41(6):1162-1164. doi: 10.1007/s10875-021-01039-x. Epub 2021 Apr 16.

Authors

George P Drewett^{1

2}, Ana Copaescu^{3

4}, Effie Mouhtouris^{5

3}, Natalie Hannan⁶, Fiona James^{5

3}, Olivia Smibert⁵, Natasha E Holmes^{5

3

7

8}, Jason A Trubiano^{5

3

7

9

10}

Affiliations

¹ Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia. gdrewett@gmail.com.
² Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia. gdrewett@gmail.com.
³ Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.
⁴ Department of Clinical Immunology and Allergy, McGill University Health Center, Montréal, Canada.
⁵ Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.
⁶ Therapeutics Discovery and Vascular Function Laboratory, Translational Obstetrics Group, Department of Obstetrics & Gynaecology, The University of Melbourne, Heidelberg, Victoria, Australia.
⁷ Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia.
⁸ Department of Medicine and Radiology, Melbourne Medical School, The University of Melbourne, Parkville, Victoria, Australia.
⁹ Department of Oncology, Sir Peter MacCallum Cancer Centre, The University of Melbourne, Parkville, Victoria, Australia.
¹⁰ The National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.

No abstract available

Publication types

Letter
Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Acute Disease
COVID-19 / immunology*
Cohort Studies
Cytokine Release Syndrome / immunology*
Female
Humans
Interleukin-1 / blood
Interleukin-6 / blood
Male
Molecular Targeted Therapy
Monitoring, Physiologic
Prospective Studies
SARS-CoV-2 / physiology*
Treatment Outcome
Tumor Necrosis Factor-alpha / blood

Substances

Interleukin-1
Interleukin-6
Tumor Necrosis Factor-alpha