NLRP3 as a sensor of metabolism gone awry

Emilia Neuwirt; Oliver Gorka; Benedikt S Saller; Christina J Groß; Tobias Madl; Olaf Groß

doi:10.1016/j.copbio.2021.03.009

NLRP3 as a sensor of metabolism gone awry

Curr Opin Biotechnol. 2021 Apr:68:300-309. doi: 10.1016/j.copbio.2021.03.009. Epub 2021 Apr 13.

Authors

Emilia Neuwirt¹, Oliver Gorka², Benedikt S Saller³, Christina J Groß⁴, Tobias Madl⁵, Olaf Groß⁶

Affiliations

¹ Institute of Neuropathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
² Institute of Neuropathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
³ Institute of Neuropathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
⁴ CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.
⁵ Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology & Biochemistry, Medical University of Graz, Graz 8010, Austria; BioTechMed-Graz, Graz 8010, Austria.
⁶ Institute of Neuropathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany. Electronic address: olaf.gross@uniklinik-freiburg.de.

PMID: 33862489
DOI: 10.1016/j.copbio.2021.03.009

Abstract

The NLRP3 inflammasome is an important player in innate immunity and pathogenic inflammation. Numerous studies have implicated it in sensing endogenous danger signals, yet the precise mechanisms remain unknown. Here, we review the current knowledge on the organismal and cellular metabolic triggers engaging NLRP3, and the mechanisms involved in integrating the diverse signals.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Immunity, Innate
Inflammasomes*
Inflammation
NLR Family, Pyrin Domain-Containing 3 Protein* / genetics

Substances

Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein