Changes in treatment of community-onset Clostridioides difficile infection after release of updated guidelines, Atlanta, Georgia, 2018

Anaerobe. 2021 Aug:70:102364. doi: 10.1016/j.anaerobe.2021.102364. Epub 2021 Apr 14.

Abstract

Updated Clostridioides difficile infection (CDI) guidelines published in 2018 recommend vancomycin as first-line treatment. Of 833 community-onset CDI cases in metropolitan Atlanta, Georgia in 2018, over half did not receive first-line treatment, although guideline adherence increased over the year. Second-line treatment was more common in patients treated in ambulatory settings.

Keywords: Clostridioides difficile infection; Guideline-adherent treatment; Metronidazole; Vancomycin.

MeSH terms

  • Adult
  • Aged
  • Anti-Bacterial Agents / standards
  • Anti-Bacterial Agents / therapeutic use*
  • Clostridioides difficile / drug effects*
  • Clostridioides difficile / physiology
  • Clostridium Infections / drug therapy*
  • Clostridium Infections / microbiology
  • Cohort Studies
  • Community-Acquired Infections / drug therapy*
  • Community-Acquired Infections / microbiology
  • Female
  • Georgia
  • Guidelines as Topic
  • Humans
  • Male
  • Metronidazole / standards
  • Metronidazole / therapeutic use
  • Middle Aged
  • Vancomycin / standards
  • Vancomycin / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Metronidazole
  • Vancomycin