Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes

Circ Res. 2021 Jun 25;129(1):e1-e20. doi: 10.1161/CIRCRESAHA.119.316386. Epub 2021 Apr 14.

Abstract

[Figure: see text].

Keywords: atrioventricular block; cardiac electrophysiology; exercise; ion channels; microRNAs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials*
  • Animals
  • Atrioventricular Block / chemically induced
  • Atrioventricular Block / diagnosis
  • Atrioventricular Block / metabolism*
  • Atrioventricular Block / physiopathology
  • Atrioventricular Node / metabolism*
  • Atrioventricular Node / physiopathology
  • Atropine
  • Biopsy
  • Calcium Channels, L-Type / genetics
  • Calcium Channels, L-Type / metabolism*
  • Disease Models, Animal
  • Electrocardiography
  • Heart Rate*
  • Horses
  • Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels / genetics
  • Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels / metabolism*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • MicroRNAs / genetics
  • MicroRNAs / metabolism
  • Myocytes, Cardiac / metabolism*
  • Physical Conditioning, Animal
  • Physical Endurance*
  • Propranolol
  • Swimming
  • Transcription, Genetic

Substances

  • Calcium Channels, L-Type
  • Hcn4 protein, mouse
  • Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
  • L-type calcium channel alpha(1C)
  • MIRN432 microRNA, mouse
  • MicroRNAs
  • Mirn211 microRNA, mouse
  • Atropine
  • Propranolol